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A comprehensive collection of research articles, scientific papers, and relevant publications produced by the Breast Health Working Group International, providing valuable insights and contributing to the global knowledge base in the field of breast health and breast cancer research. 1.   18F-FDG PET/CT in Early Stage Breast Cancer Comes with Financial Burden. https://www.facs.org/for-medical-professionals/news-publications/news-and-articles/bulletin/2024/julyaugust-2024-volume-109-issue-7/18f-fdg-petct-in-early-stage-breast-cancer-comes-with-financial-burden/. Atilla Soran, MD, MPH, FACS, Mehmet Ali Nazlı, MD, Osman Toktas, MD, and Serdar Ozbas, MD, FEBS 2.   Intervention for Hepatic and Pulmonary Metastases in Breast Cancer Patients: Prospective, Multi-instutional Registry Study-IMET, Protocol MF 14-02. https://pubmed.ncbi.nlm.nih.gov/35876920/ Soran et al. Annals of Surgical Oncology volume 29, pages6327–6336 (2022). The surgical resection or ablative interventions may contribute to the survival of breast cancer patients with a limited number and operable metachronous hepatic/pulmonary metastases. 3.   Locoregional Therapy for Intact Primary Tumor in De Novo Stage IV Breast Cancer. https://pubmed.ncbi.nlm.nih.gov/35820106/. Soran et al. Correspondence. Journal of Clinical Oncology 2022 40:33, 3897-3898 https://doi.org/10.1200/JCO.22.00802. In light of this discussion, we shared our concerns that the LRT does not provide a survival advantage in dn stage IV BC. 4.   The Effect of Primary Surgery in Patients with De Novo Stage IV Breast Cancer with Bone Metastasis Only (Protocol BOMET MF 14-01): A Multi-Center, Prospective Registry Study. https://pubmed.ncbi.nlm.nih.gov/33532878/ Soran et al. Ann Surg Oncol​. 2021 Sep;28(9):5048-5057. doi: 10.1245/s10434-021-09621-8. Epub 2021 Feb 2. The LRT prolonged overall survival and SPFS and decrease locoregional recurrence in a median 3 year follow up. Timing of primary breast surgery either at diagnosis or after ST provided a similar survival benefit compare with ST alone in de novo stage IV BOM BC patients.  5.   Correspondence to ‘’ Locoregional therapy in de novo metastatic breast cancer: Systematic review and meta-analysis, written by Reinhorn D et al. https://pubmed.ncbi.nlm.nih.gov/34654601/  In The Breast Journal 58 (2021) 173-181’’. Soran et al. In The Breast Journal 58 (2021) 173e181”, The Breast, https://doi.org/10.1016/j.breast.2021.10.002. There is a group of patients, such as having low tumor burden and bone metastatic group, has a survival benefit when cautiously evaluated for primary breast surgery in de novo stage IV BC. 6.   The role of loco-regional treatment in long-term quality of life in de novo stage IV breast cancer patients: protocol MF07-01Q. https://pubmed.ncbi.nlm.nih.gov/33242163/.     Soran et al. Supportive Care in Cancer, Springer 2020, DOI 10.1007/s00520-020-05905-z. Patient who had LRT has similar physical and mental health outcomes compared to ST only in a cohort of patients who lived longer than three years. 7.   A Novel First-Line Treatment Alternative for Noncomplicated Idiopathic Granulomatous Mastitis: Combined Intralesional Steroid Injection with Topical Steroid Administration. https://pubmed.ncbi.nlm.nih.gov/34012373/ Toktas et al. Breast Care 2021;16:181–187 DOI: 10.1159/000507951. The comparison between the efficacy of combined intralesional  steroid injection with topical steroid administration to systemic streoid therapy in the treatment of noncomplicated IGM. 8.   Loco-Regional Treatment for Intact Primary Tumor in Patient with De Novo Metastatic Breast Cancer; Comments and Concerns of ECOG-ACRIN 2018 Trial. https://pubmed.ncbi.nlm.nih.gov/32656512/ Soran et al.Eur J Breast Health 2020; 16(3): 158-159DOI: 10.5152/ejbh.2020.080620. It is important to achieve local control in oligometastatic cases, especially in patients with bone only metastases. In addition, surgical removal of the primary tumor is important to prevent local spread to the pleura and pericardium. 9.   Are we close to the end of primary tumor resection discussion for de novo stage IV BC? https://pubmed.ncbi.nlm.nih.gov/30528045/  A.Soran, European Journal of Surgical Oncology (2018), https://doi.org/10.1016/j.ejso.2018.09.022. LRT should be considered in selected cases; oncologists must consider age, performance status, comorbidities, tumor type, and metastatic disease burden while discussing LRT with patients. 10.                Randomized Trial Comparing Resection of Primary Tumor with No Surgery in Stage IV Breast Cancer at Presentation: Protocol MF07-01. https://pubmed.ncbi.nlm.nih.gov/29777404/ Soran et al. Ann Surg Oncol. 2018 Oct;25(11):3141-3149. doi: 10.1245/s10434-018-6494-6.  The first randomized controlled trial in denovo metastatic breast cancer. 11.                Factors related to recurrence of idiopathic granulomatous mastitis what do we learn from a multicentre study? https://pubmed.ncbi.nlm.nih.gov/29777404/  Uysal et al. doi: 10.1111/ans.14115. Having a history of pregnancy, breastfeeding, breast infection, and smoking increases the risk of IGM recurrence. However, the treatments examined in this study did not affect the recurrence of IGM. 12.                ASO Author Reflections: Is Intensifying Loco-Regional treatment In the Early Course of De Novo Stage IV Breast Cancer Reasonable? https://pubmed.ncbi.nlm.nih.gov/30357577/  The evolution of LRT to BC from past to future. A.Soran, A brief invited commentary on the article. 13.                Validation of breast cancer nomograms for predicting the non-sentinel lymph node metastases after a positive sentinel lymph node biopsy in a multi-center study. https://pubmed.ncbi.nlm.nih.gov/19535217/ Gur et al.2009 Elsevier, doi:10.1016/j.ejso.2009.05.007. Various nomograms were assessed to detect non-sentinel lymph node metastasis (NSLNM) in breast cancer patients with positive sentinel lymph nodes (SLN).

Title
Authors
Journal
Publication date
Summary
18F-FDG PET/CT in Early Stage Breast Cancer Comes with Financial Burden
FACS Bulletin, 2024, https://www.facs.org/for-medical-professionals/news-publications/news-and-articles/bulletin/2024/julyaugust-2024-volume-109-issue-7/18f-fdg-petct-in-early-stage-breast-cancer-comes-with-financial-burden/
Atilla Soran, MD, MPH, FACS, Mehmet Ali Nazlı, MD, Osman Toktas, MD, Serdar Ozbas, MD, FEBS
2024
Discusses financial implications of PET/CT in early-stage breast cancer.
Navigating Lymphedema: The Impact of Indocyanine Green Lymphography on Personalized Therapy Outcomes in Breast Cancer Patients
Soran A, Senol K, Lupinacci K. Navigating Lymphedema: The Impact of Indocyanine Green Lymphography on Personalized Therapy Outcomes in Breast Cancer Patients. Clin Breast Cancer. Published online October 18, 2024. doi:10.1016/j.clbc.2024.10.010
Atilla Soran 1, Kazim Senol 2, Kristin Lupinacci 1
2024
Intervention for Hepatic and Pulmonary Metastases in Breast Cancer Patients: Prospective, Multi-institutional Registry Study-IMET, Protocol MF 14-02
Soran A, Ozbas S, Ozcinar B, et al. Intervention for Hepatic and Pulmonary Metastases in Breast Cancer Patients: Prospective, Multi-institutional Registry Study-IMET, Protocol MF 14-02 [published correction appears in Ann Surg Oncol. 2023 Feb;30(2):1074. doi: 10.1245/s10434-022-12931-0]. Ann Surg Oncol. 2022;29(10):6327-6336. doi:10.1245/s10434-022-12239-z
Atilla Soran 1, S Ozbas 2, B Ozcinar 3, A Isik 4, L Dogan 5, K Senol 6, A Dag 7, H Karanlik 8 9, O Aytac 10, G Karadeniz Cakmak 11, K Dalci 12, M Dogan 13, Y A Sezer 13, S Gokgoz 6, E Ozyar 14, E Sezgin 15; Breast Health Working Group International
2022
Evaluates survival benefits of resection or ablation in patients with operable hepatic/pulmonary metastases.
Locoregional Therapy for Intact Primary Tumor in De Novo Stage IV Breast Cancer
Soran A, Aytac O, Ozbas S. Locoregional Therapy for Intact Primary Tumor in De Novo Stage IV Breast Cancer. J Clin Oncol. 2022;40(33):3897-3898. doi:10.1200/JCO.22.00802
Atilla Soran 1, Ozgur Aytac 1, Serdar Ozbas 1
2022
Examines LRT in Stage IV breast cancer, suggesting no survival advantage.
A Novel First-Line Treatment Alternative for Noncomplicated Idiopathic Granulomatous Mastitis: Combined İntralesional Steroid İnjection with Topical Steroid Administration
Toktas O, Konca C, Trabulus DC, et al. A Novel First-Line Treatment Alternative for Noncomplicated Idiopathic Granulomatous Mastitis: Combined İntralesional Steroid İnjection with Topical Steroid Administration. Breast Care (Basel). 2021;16(2):181-187. doi:10.1159/000507951
Osman Toktas 1, Can Konca 2, Didem Can Trabulus 3, Aykut Soyder 4, Hande Koksal 5, Hasan Karanlik 6, Ayfer Kamali Polat 7, Serdar Ozbas 8, Serdar Yormaz 9, Arda Isik 10, Efe Sezgin 11, Atilla Soran 12
2021
Compares combined steroid treatments to systemic therapy in IGM patients.
The role of loco-regional treatment in long-term quality of life in de novo stage IV breast cancer patients: protocol MF07-01Q
Soran A, Soyder A, Ozbas S, et al. The role of loco-regional treatment in long-term quality of life in de novo stage IV breast cancer patients: protocol MF07-01Q. Support Care Cancer. 2021;29(7):3823-3830. doi:10.1007/s00520-020-05905-z
Atilla Soran 1 2, Aykut Soyder 3, Serdar Ozbas 4, Vahit Ozmen 5, Hasan Karanlik 6, Abdullah Igci 5, Mahmut Muslumanoglu 5, Turkkan Evrensel 7, Zafer Canturk 8, Zafer Utkan 8, Cihangir Ozaslan 9, Cihan Uras 10, Umit Ugurlu 11, Cavit Col 12, Neslihan Cabioglu 5, Ali Uzunkoy 13, Bahadır M Gulluoglu 11, Ergun Erdem 14, Can Konca 15, Efe Sezgin 16; Breast Health Working Group International
2021
Analyzes LRT's impact on QoL, noting similar outcomes compared to systemic therapy.
ASO Author Reflections: Locoregional Therapy in De Novo Bone-Only Metastatic Breast Cancer Provides Survival Advantage Regardless of Therapy Sequencing
Soran A, Dogan L, Ozbas S. ASO Author Reflections: Locoregional Therapy in De Novo Bone-Only Metastatic Breast Cancer Provides Survival Advantage Regardless of Therapy Sequencing. Ann Surg Oncol. 2021;28(9):5058. doi:10.1245/s10434-021-09664-x
Atilla Soran, Lütfi Dogan, Serdar Ozbas
2021
Commentary on LRT's evolution in breast cancer treatment.
The Effect of Primary Surgery in Patients with De Novo Stage IV Breast Cancer with Bone Metastasis Only (Protocol BOMET MF 14-01): A Multi-Center, Prospective Registry Study
Soran A, Dogan L, Isik A, et al. The Effect of Primary Surgery in Patients with De Novo Stage IV Breast Cancer with Bone Metastasis Only (Protocol BOMET MF 14-01): A Multi-Center, Prospective Registry Study. Ann Surg Oncol. 2021;28(9):5048-5057. doi:10.1245/s10434-021-09621-8
Atilla Soran, Lutfi Dogan, Arda Isik, Serdar Ozbas, Didem Can Trabulus, Umut Demirci, Hasan Karanlik, Aykut Soyder, Ahmet Dag, Ahmet Bilici, Mutlu Dogan, Hande Koksal, Mehmet Ali Nahit Sendur, Mehmet Ali Gulcelik, Gokturk Maralcan, Neslihan Cabioglu, Levent Yeniay, Zafer Utkan, Turgay Simsek, Nuri Karadurmus, Gul Daglar, Birol Yildiz, Cihan Uras, Mustafa Tukenmez, Ahmet Yildirim, Suat Kutun, Cihangir Ozaslan, Niyazi Karaman, Müfide Nuran Akcay, Osman Toktas, Efe Sezgin
2021
Reports LRT benefits, showing survival improvement in bone-only metastasis cases.
Correspondence to "Locoregional therapy in de novo metastatic breast cancer: Systematic review and meta-analysis, written by Reinhorn D et al. In The Breast Journal 58 (2021) 173-181"
Soran A, Ozbas S, Dogan L, Isik A, Sezgin E; Breast Health Working Group International.. Correspondence to "Locoregional therapy in de novo metastatic breast cancer: Systematic review and meta-analysis, written by Reinhorn D et al. In The Breast Journal 58 (2021) 173-181". Breast. 2021;60:304-305. doi:10.1016/j.breast.2021.10.002
Atilla Soran 1, Serdar Ozbas 2, Lutfi Dogan 3, Arda Isik 4, Efe Sezgin 5; Breast Health Working Group International.
2021
Suggests potential survival benefits for selected patients with low tumor burden.
Loco-Regional Treatment for Intact Primary Tumor in Patient with De Novo Metastatic Breast Cancer; Comments and Concerns of ECOG-ACRIN 2108 Trial
Soran A, Özbaş S, Doğan L, Sezgin E, Özmen V, Beriwal S, Brufsky A. Loco-Regional Treatment for Intact Primary Tumor in Patient with De Novo Metastatic Breast Cancer; Comments and Concerns of ECOG-ACRIN 2108 Trial. Eur J Breast Health. 2020 Jun 8;16(3):158-159. doi: 10.5152/ejbh.2020.080620. PMID: 32656512; PMCID: PMC7337916.
Atilla Soran, Serdar Özbaş, Lütfi Doğan, Efe Sezgin, Vahit Özmen, Sushil Beriwal, Adam Brufsky, On behalf of The Breast Disease Working Group
2020
Highlights LRT importance in local control for bone-only metastasis cases.
Are we close to the end of the primary tumor resection discussion for de novo stage IV BC?
Soran A. Are we close to the end of the primary tumor resection discussion for de novo stage IV BC?. Eur J Surg Oncol. 2019;45(2):81-82. doi:10.1016/j.ejso.2018.09.022
Atilla Soran
2018
Discusses selective cases where LRT may be beneficial.
Randomized Trial Comparing Resection of Primary Tumor with No Surgery in Stage IV Breast Cancer at Presentation: Protocol MF07-01
Soran A, Ozmen V, Ozbas S, et al. Randomized Trial Comparing Resection of Primary Tumor with No Surgery in Stage IV Breast Cancer at Presentation: Protocol MF07-01. Ann Surg Oncol. 2018;25(11):3141-3149. doi:10.1245/s10434-018-6494-6
Atilla Soran, Vahit Ozmen, Serdar Ozbas, Hasan Karanlik, Mahmut Muslumanoglu, Abdullah Igci, Zafer Canturk, Zafer Utkan, Cihangir Ozaslan, Turkkan Evrensel, Cihan Uras, Erol Aksaz, Aykut Soyder, Umit Ugurlu, Cavit Col, Neslihan Cabioglu, Betül Bozkurt, Ali Uzunkoy, Neset Koksal, Bahadir M Gulluoglu, Bulent Unal, Can Atalay, Emin Yıldırım, Ergun Erdem, Semra Salimoglu, Atakan Sezer, Ayhan Koyuncu, Gunay Gurleyik, Haluk Alagol, Nalan Ulufi, Uğur Berberoglu, Mustafa Dulger, Omer Cengiz, Efe Sezgin, Ronald Johnson
2018
First RCT in metastatic breast cancer, comparing resection and non-surgical options.
Factors Related to Idiopathic Granulomatous Mastitis Recurrence
Uysal E, Soran A, Sezgin E; Granulomatous Mastitis Study Group. Factors related to recurrence of idiopathic granulomatous mastitis: what do we learn from a multicentre study?. ANZ J Surg. 2018;88(6):635-639. doi:10.1111/ans.14115
Erdal Uysal, Atilla Soran, Efe Sezgin, Granulomatous Mastitis Study Group
2018
Identifies factors affecting IGM recurrence, including breastfeeding and smoking.
Validation of breast cancer nomograms for predicting the non-sentinel lymph node metastases after a positive sentinel lymph node biopsy in a multi-center study
Gur AS, Unal B, Ozbek U, et al. Validation of breast cancer nomograms for predicting the non-sentinel lymph node metastases after a positive sentinel lymph node biopsy in a multi-center study. Eur J Surg Oncol. 2010;36(1):30-35. doi:10.1016/j.ejso.2009.05.007
A.S. Gur, B. Unal, U. Ozbek, V. Ozmen, F. Aydogan, S. Gokgoz, B.M. Gulluoglu, E. Aksaz, S. Ozbas, S. Baskan, A. Koyuncu, A. Soran, For the Turkish Federation of Breast Disease Associations Protocol MF08-01 investigators
2010
Assesses nomograms for detecting metastasis in non-sentinel lymph nodes.
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